Tgf-β1 transcriptionally promotes 90K expression: possible implications for cancer progression
نویسندگان
چکیده
منابع مشابه
Neuropilin-2 Expression Promotes TGF-β1-Mediated Epithelial to Mesenchymal Transition in Colorectal Cancer Cells
Neuropilins, initially characterized as neuronal receptors, act as co-receptors for cancer related growth factors and were recently involved in several signaling pathways leading to cytoskeletal organization, angiogenesis and cancer progression. Then, we sought to investigate the ability of neuropilin-2 to orchestrate epithelial-mesenchymal transition in colorectal cancer cells. Using specific ...
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Transforming growth factor-β1 (TGF-β1) signaling and high mobility group A (HMGA1) are known to play essential roles in the progression of breast cancer by inducing epithelial-mesenchymal transition. However, the correlation between TGF-β1 and HMGA1 in breast cancer cell is not yet well understood. In this study, we determined the effects of TGF-β1 on HMGA1 expression in breast cancer cells and...
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Some feedback pathways are critical in the process of tumor development or malignant progression. However the mechanisms through which these pathways are epigenetically regulated have not been fully elucidated. Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit that was implicated in malignant progression of tumors and...
متن کاملCDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression. Here we show that CDK5 is commonly overexpressed and significantly correlated with several poor prognostic parameters of breast cancer. We found that CDK5 participated in TG...
متن کاملERRATUM: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
The details for affiliations 1–3 were incorrect in the original HTML version of this Article. The affiliations were incorrectly listed as including ‘‘Auckland, New Zealand’’. These affiliations should include ‘‘Changchun, China’’. The correct affiliations are listed above. This has now been corrected in theHTML and PDF version of the Article. SUBJECT AREAS: CANCER BREAST CANCER CELL SIGNALLING ...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2021
ISSN: 2058-7716
DOI: 10.1038/s41420-021-00469-1